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Ninja Nerds!

In this episode of the Ninja Nerd Podcast, Zach and Rob walk you through a high-yield, case-based approach to Gonorrhea, focusing on how to recognize common presentations, diagnose infection accurately, and manage both uncomplicated and disseminated disease. This is one of the most important sexually transmitted infections in medicine because of its prevalence, complications, and evolving antibiotic resistance.

We start with classic presentations of urethritis and cervicitis, breaking down symptoms like dysuria, purulent discharge, pelvic pain, and abnormal bleeding. From there, we explain how Neisseria gonorrhoeae infects mucosal surfaces and why many patients, especially women, may have minimal or no symptoms despite ongoing infection.

Next, we focus on diagnosis and treatment, including nucleic acid amplification testing, Gram stain findings, and current first-line antibiotic therapy. We also highlight important considerations for coinfection with Chlamydia trachomatis, partner treatment strategies, and the growing clinical importance of antimicrobial resistance.

Finally, we cover high-yield complications and special scenarios, including pelvic inflammatory disease, epididymitis, infertility, neonatal conjunctivitis, and disseminated gonococcal infection with septic arthritis and dermatitis.

Let’s get into it, Ninja Nerds!

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